Search results for "Acetylsalicyclic acid"

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Wechselwirkungen zwischen Acetylsalicylsäure und Lysin in Lösung

1985

Der pH-abhangige Einflus von Lysin auf die Hydrolyse von Acetylsalicylsaure zu Salicylsaure und auf die Bildung von Lysinderivaten der Acetylsalicylsaure wurde durch HPLC-Untersuchungen geklart. Die Bildung von e-N-Acetyl-lysin, α-N-Acetyl-lysin und wenig Diacetyl-lysin erfolgt rasch bei pH-Werten der Losung von 6 und hoher, sehr langsam jedoch bei dem fur gebrauchliche Injektionslosungen eingestellten pH-Wert 5. Das Auftreten des postulierten Salicyloyllysins in Acetylsalicylsaure-Lysin-Losungen wurde durch Vergleich mit der unabhangig synthetisierten Verbindung ausgeschlossen. Interactions of Acetylsalicyclic Acid and Lysine in Solution The influence of lysine on the hydrolysis, and on th…

HydrolysisAcetylsalicyclic acidStereochemistryChemistryDrug DiscoveryLysinePharmaceutical SciencePh dependentHigh-performance liquid chromatographyArchiv der Pharmazie

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